أضخم موقع علمي صحي موثق في العالم لسعادة العائلة وصحتها, بالعلم والإيمان نبني الميزان

86004127

Study of Hypocholesterolemic and Antiatherosclerotic Properties of Medicago sativa L. Cultivated in Egypt.

Study of Hypocholesterolemic and Antiatherosclerotic Properties of Medicago sativa L. Cultivated in Egypt.



 

         
  No.  Divisions/Titles for Abstract Details

 
  1 Abstract Title Study of Hypocholesterolemic and Antiatherosclerotic Properties of Medicago sativa L. Cultivated in Egypt.  
  2 Abstract Source  Journal of Food and Drug Analysis, 13.  
  3 Abstract Author(s) Khaleel, A. E., Gad, M. Z., El-Maraghy, S. A., Hifnawy, M. S. & Abdel-Sattar, E.  
  4 Article Affiliation Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.  
  5 Abstract Alfalfa (Alfalfa(Medicago sativa)also called Lucerne, is naturally high in many essential vitamins and minerals, including A, D, E, K, and even the full family of B vitamins; biotin, calcium, folic acid, iron, magnesium, potassium and many others, as well as being very high in protein, especially when dried. It is "The king of all foods"!)was reported to be hypocholesterolemic (reducing cholesterol level in body)and antiatherosclerotic (substances decreasing the atherosclerosis level). Saponin glycosides (Saponins are a class of chemical compounds found in particular abundance in various plant species. More specifically, they are amphipathic glycosides grouped phenomenologically by the soap-like foaming they produce when shaken in aqueous solutions, and structurally by having one or more hydrophilic glycoside moieties combined with a lipophilic triterpene derivative) were suggested to be responsible for this activity by neutralizing cholesterol (a waxy, fat-like substance that occurs naturally in all parts of the body. Your body needs some cholesterol to work properly)in the stomach, enabling it to be excreted from the body. This makes alfalfa superior to the current anti-cholesterol medications which act by blocking cholesterol synthesizing apparatus. This study was undertaken in an attempt to prepare an alfalfa extract with high saponin content and free or low content of other toxic constituents found in alfalfa (canavanine and coumestrol), which causes serious side effects. A patent process was used to render alfalfa toxin free and to produce a drug present in the international market. Our study is based on monitoring the Egyptian crop at two different localities for its saponin, canavanine and coumestrol contents at different growth stages. The study showed that the tested extract of the chosen stage to be biologically studied (hypocholesterolemic and antiatherosclerotic effects) on the basis of the highest saponin content was just before fruiting stage of the locality A. This stage was free from both coumestrol and canavanine. The study proved that the Egyptian crop of alfalfa was found to safely reduce natural cholesterol and to possess a strong antiatherosclerotic activity. This extract (I) produced the most significant decrease in total cholesterol and LDL-cholesterol by 85.1 and 88%, respectively, of the corresponding levels in hypercholesterolemic rabbits. This decrease is more significant than that produced by gemfibrozil (73 and 74%) upon concomitant administration with a cho-lesterol enriched diet using the same animal model at the tested dose level. Also, it was obvious that all alfalfa preparations produced significant antioxidant properties. All alfalfa extracts possessed antiatherosclerotic activity as observed by the almost normalization of the aortic sections upon concomitant use of alfalfa extracts with cholesterol-enriched diet.  
  6 Summary Alfalfa was reported to be hypocholesterolemic and antiatherosclerotic. Saponin glycosides were suggested to be responsible for this activity by neutralizing cholesterol in the stomach, enabling it to be excreted from the body. This makes alfalfa superior to the current anti-cholesterol medications which act by blocking cholesterol synthesizing apparatus. This study was undertaken in an attempt to prepare an alfalfa extract with high saponin content and free or low content of other toxic constituents found in alfalfa (canavanine and coumestrol), which causes serious side effects. A patent process was used to render alfalfa toxin free and to produce a drug present in the international market. Our study is based on monitoring the Egyptian crop at two different localities for its saponin, canavanine and coumestrol contents at different growth stages. The study showed that the tested extract of the chosen stage to be biologically studied (hypocholesterolemic and antiatherosclerotic effects) on the basis of the highest saponin content was just before fruiting stage of the locality A. This stage was free from both coumestrol (Coumestrol is a natural organic compound in the class of phytochemicals known as coumestans. Coumestrol was first identified as a compound with estrogenic properties)and canavanine (is a non-proteinogenic amino acid found in certain leguminous plants. It is structurally related to the proteinogenic α-amino acid L-arginine). The study proved that the Egyptian crop of alfalfa was found to safely reduce natural cholesterol and to possess a strong antiatherosclerotic activity. This extract (I) produced the most significant decrease in total cholesterol and LDL-cholesterol by 85.1 and 88%, respectively, of the corresponding levels in hypercholesterolemic rabbits. This decrease is more significant than that produced by gemfibrozil (73 and 74%) upon concomitant administration with a cho-lesterol enriched diet using the same animal model at the tested dose level. Also, it was obvious that all alfalfa preparations produced significant antioxidant (a substance that inhibits oxidation, especially one used to counteract the deterioration of stored food products)properties. All alfalfa extracts possessed antiatherosclerotic activity as observed by the almost normalization of the aortic sections upon concomitant use of alfalfa extracts with cholesterol-enriched diet.  
  7 Article Published Date May-2005  
  8
Study Type invitro  
  9
Substances alfalfa  
  10
Diseases Hypercholesterimia  
  11 Pharmacological Actions Hypocholesterimia  
  12
Link https://goo.gl/BdydHN  
       

 


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